I just discovered this one yesterday (through Kim Kommando). KnujOn (pronounced "nudge on") goes after spam at the source: the companies sending it.
You don't need to join, either (though you can if you want be updated). Just send any spam e-mails to firstname.lastname@example.org. You can include the headers if you want, but they don't require them. There are also other addresses to target specific types of spam.
Knujon takes the information and goes after websites that allow spammers. They have shut down over 30,000 of them.
This won't end spam, but it should help.